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Polyacrylic Resin Ⅰ
Product Details
Category
Binder Excipients
Molecular Formula
(C17H26O8)n
Molecular Weight
250000
Grade
Pharmceutical Excipients
UNII
NX76LV5T8J
Chemical Name
Methacrylic acid/ ethyl acrylate copolymer(1:1)
CAS Number
25212-88-8
Synonyms
Methacrylic Acid Copolymer (USP); Methacrylic Acid - Ethyl Acrylate Copolymer (1:1)(BP); Acidi methacrylici et ethylis acrylatis polymerisatum 1:1(PhEur)
Administration route
Oral
Dosage Form
Oral capsules and tablets
Stability and Storage Conditions
The polymer in dry powder state is stable at temperatures below 30°C. Above this temperature, the powder is easy to agglomerate, but this phenomenon does not affect the quality of the material, and the lumps are easy to crush. The polymer in dry powder state is stable for 3 years when stored in a sealed container at a temperature below 30°C. Aqueous dispersions are very sensitive to temperature and delamination occurs below 0°C. Therefore, the water dispersion should be transported and stored in a sealed container at a temperature of 5-25°C, and it is stable for at least 18 months after delivery from the manufacturer's warehouse.
Source and Preparation
Polymerized from acrylic and methacrylic acid or their various esters.
Applications
It can be used as film coating material; tablet binder; tablet diluent. Polyacrylic resins are mainly used as film coating materials for oral tablets and capsules. Films of different types of polymers have different dissolution characteristics. Eudragit L and S types are used as enteric-coated materials because they are insoluble in gastric juice. Different models dissolve at different pHs. Eudragit L30D-55 is used as an enteric coating material for solid preparations, which cannot be tolerated in the stomach, but is easily dissolved when the pH is above 5.5. Eudragit L100-55 can replace Eudragit L30D-55, and the commercially available product is redispersible powder.
Safety
Acrylic resins are widely used as film coating materials for oral pharmaceutical dosage forms. Non-toxic, non-irritating, also used in topical preparations. Taking 2mg of Eudragit per kilogram of body weight per day (equivalent to about 150mg for adults) is basically safe for humans.
Incompatibilities
The incompatibility of polymer aqueous dispersion mainly depends on the ionization and physical properties of polymer and solvent. For example, coagulation can be caused by electrolyte solution, pH change, some organic solvents, too high or too low temperature, etc. The aqueous dispersion of Eudragit L100-55 is not compatible with magnesium stearate. Although solutions of solid acrylic resins and organic solvents are compatible with more drugs than their aqueous dispersions, reactions with some drugs may still occur.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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