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Powdered Cellulose
Product Details
Category
Adsorbents; Glidants; Suspending Agentss; Diluents; Disintegrating Agentss
Molecular Formula
(C6H10O5)n, n≈500
Molecular Weight
≈243 000 Since cellulose is extracted from natural polymers, the chain lengths can vary, as can the molecular weight.
Grade
Pharmceutical Excipients
Description
Powdered cellulose occurs as a white or almost white, odorless and tasteless powder of various particle sizes, ranging from a freeflowing fine or granular dense powder, to a coarse, fluffy, nonflowing material.
UNII
SMD1X3XO9M
Chemical Name
Cellulose
CAS Number
9004-34-6
Synonyms
Cellulose, Powdered; Alpha-cellulose; Arbocel; cellulosi pulvis; E460; Elcema; KC Flock; Microcel 3E-150; Sanacel; Sanacel Pharma; Sancel-W; Solka-Floc
Administration route
Oral; Dental; Sublingual; Oral; Topical
Dosage Form
Toothpaste, tablets (including sustained and controlled release preparations, etc.), capsules, drops, dry suspensions, etc.
Stability and Storage Conditions
Powdered cellulose is a stable, slightly hygroscopic substance; it should be kept in an airtight container in a cool, dry place.
Commonly used amount and the maximum amount
Capsule filler: 0~100%; tablet binder: 5%~25%; tablet disintegrant: 5%~15%; tablet glidant: 1%~2%.
Source and Preparation
The α-cellulose slurry obtained from fibrous plants is purified and mechanically reduced to obtain powdery cellulose.
Safety
Powdered cellulose is widely used in oral pharmaceutical preparations and food, and is a non-toxic and non-irritating substance. However, allergic reactions may occur when inhaled, ingested, or in contact with the skin. Powdered cellulose is not absorbed after oral administration and therefore has little toxicity. Cellulose used as a formulation excipient does not cause diarrhea, however, consumption of large amounts of cellulose may act as a laxative. Abuse of preparations containing cellulose by inhalation or injection can lead to the formation of fibrous granulomas. LD50 (rat, oral): >5 g/kg; LD50 (rat, inhalation): 5.8 g/m³/4 h; LD50 (rabbit, dermal): >2 g/kg
Incompatibilities
Incompatibility with strong oxidizing agents.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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