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Alendronate sodium
Product Details
Molecular Formula
C4H13NO7P2.3H2O.Na
Molecular Weight
326.13
Appearance
Solid
Grade
Pharmaceutical grade
Standard
USP
Description
Alendronate sodium is the sodium salt form of alendronic acid, serving as the active pharmaceutical ingredient (API) in the nitrogen-containing bisphosphonate class. It acts as a potent and specific inhibitor of bone resorption by selectively binding to hydroxyapatite crystals at sites of active bone remodeling, where it is internalized by osteoclasts and disrupts the mevalonate pathway, ultimately leading to osteoclast apoptosis and a significant reduction in bone turnover.
CAS Number
121268-17-5
Stability and Storage Conditions
Store in freezer
Solubility
water, double-distilled: 10 mg/mL
Storage
-20°C
Melting Point
245°C
Applications
The Alendronate sodium is primarily used in the manufacture of oral tablets for the treatment and prevention of osteoporosis in postmenopausal women and men, as well as for the management of glucocorticoid-induced osteoporosis. Its applications include increasing bone mineral density, reducing the risk of vertebral and hip fractures, and treating Paget's disease of bone to normalize elevated bone turnover and alleviate associated symptoms.
Color
White
MDL number
MFCD01748233
SMILES
C(O)(CCCN)(P([O-])(=O)O)P(=O)(O)O.[Na+].O.O.O
InChI
InChI=1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
Water Solubility
Soluble in water at 10mg/ml
InChI Key
NKENDYHBVCKCNL-UHFFFAOYSA-M
WGK Germany
3
RTECS
SZ6523500
Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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