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Bendamustine hydrochloride
Product Details
Molecular Formula
C16H22Cl3N3O2
Molecular Weight
394.72
Appearance
Powder
Grade
Pharmaceutical grade
Standard
USP
Description
Bendamustine hydrochloride combines the functions of an alkylating agent (causing DNA cross-linking and strand breaks) and a purine analog (disrupting mitotic checkpoints and metabolism), leading to p53-independent apoptosis. This dual mechanism contributes to its efficacy in some alkylator-resistant tumors.
CAS Number
3543-75-7
Stability and Storage Conditions
Stable
Solubility
H2O: >30mg/mL
Storage
Room temp
Melting Point
149-151°C
Applications
Bendamustine hydrochloride is a unique bifunctional alkylating agent with both purine analog properties, used primarily in the treatment of hematologic malignancies.
EC Number
631-540-0
Color
Off-white
MDL number
MFCD01658758
SMILES
C12N=C(CCCC(=O)O)N(C)C=1C=CC(N(CCCl)CCCl)=C2.Cl
InChI
InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H
Water Solubility
H2O: >30mg/mL
InChI Key
ZHSKUOZOLHMKEA-UHFFFAOYSA-N
WGK Germany
3
RTECS
DE1590000
Toxicity
LD50 (monohydrate) in mice, rats (mg/kg): 400-500, 200-300 orally; 80, 40 i.v. (Horn)
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