Welcome to CD Formulation
Products
Cholesterol
Product Details
Category
Emollient; Emulsifying Agents
Molecular Formula
C27H46O
Molecular Weight
386.67
Grade
Pharmceutical Excipients
Description
Cholesterol occurs as white or faintly yellow, almost odorless, pearly leaflets, needles, powder, or granules. On prolonged exposure to light and air, cholesterol acquires a yellow to tan color.
UNII
97C5T2UQ7J
Chemical Name
Cholest-5-en-3β-ol
CAS Number
57-88-5
Synonyms
Cholesterin; cholesterolum
Administration route
Injections; ophthalmic, topical, and vaginal
Dosage Form
Injections; ophthalmic, topical, and vaginal preparations
Stability and Storage Conditions
Cholesterol is stable and should be stored in a well-closed container, protected from light.
Source and Preparation
The commercial material is normally obtained from the spinal cord of cattle by extraction with petroleum ethers, but it may also be obtained from wool fat. Purification is normally accomplished by repeated bromination. Cholesterol may also be produced by entirely synthetic means. Cholesterol produced from animal organs will always contain cholestanol and other saturated sterols.
Applications
Cholesterol is used in cosmetics and topical pharmaceutical formulations at concentrations of 0.3-5.0% w/w as an emulsifying agent. It imparts water-absorbing power to an ointment and has emollient activity. Cholesterol also has a physiological role. It is the major sterol of the higher animals, and it is found in all body tissues, especially in the brain and spinal cord. It is also the main constituent of gallstones.
Safety
Cholesterol is generally regarded as an essentially nontoxic and nonirritant material at the levels employed as an excipient.I t has, however, exhibited experimental teratogenic and reproductive effects, and mutation data have been reported. Cholesterol is often derived from animal sources and this must be done in accordance with the regulations for human consumption. The risk of bovine spongiform encephalopathy (BSE) contamination has caused some concern over the use of animalderived cholesterol in pharmaceutical products. However, synthetic methods of cholesterol manufacture have been developed.
Incompatibilities
Cholesterol is precipitated by digitonin.
Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
GET IN TOUCH
Enter your email here to subscribe.
Easy access to products and services you need from our library via powerful searching tools.