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Crotamiton
Product Name
Crotamiton
Cat.No.
PAP-0330
Particle Size
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Price
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Product Details
Molecular Formula
C13H17NO
Molecular Weight
203.28
Appearance
Colourless to Light Brown Liquid
Grade
Pharmaceutical grade
Description
Crotamiton is a synthetic, topical scabicidal and antipruritic agent. It is an amide formed from the condensation of crotonic acid with N-ethyl-2-methylaniline, and exists as a mixture of cis and trans isomers. Its molecular formula is C₁₃H₁₇NO and its molecular weight is 203.28. It is available as a 10% (w/w) cream or 10% (100 mg/mL) lotion for topical use only.
CAS Number
483-63-6
Stability and Storage Conditions
Light Sensitive
Solubility
Ethanol: soluble
Storage
2-8°C
Boiling Point
153-155 °C/13 mmHg (lit.)
Melting Point
25°C
Density
0.987 g/mL at 25 °C (lit.)
Applications
Crotamiton is primarily used as a scabicidal and antipruritic agent for the treatment of scabies and pruritic skin conditions. Its mechanisms of action are not fully understood. Additionally, it functions as a pharmaceutical excipient, serving as a dissolving agent and permeation enhancer in various topical preparations (e.g., loxoprofen sodium, indomethacin, ketoconazole). It has a mild local anesthetic effect, a specific killing effect on scabies mites, and inhibitory effects on streptococci and staphylococci.
Color
Colourless to Light Brown
SMILES
CCN(C(=O)\C=C\C)c1ccccc1C
InChI
1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+
Water Solubility
Soluble in water (1:500), alcohol, methanol, ether, and ethanol.
InChI Key
DNTGGZPQPQTDQF-XBXARRHUSA-N
WGK Germany
3
LogP
3.099 (est)
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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