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D-Proline
Product Details
Molecular Formula
C5H9NO2
Molecular Weight
115.13
Appearance
White to yellow powder
Grade
Pharmaceutical grade
Standard
USP/EP
Description
D‑Proline is the non‑natural enantiomer of proline, distinguished by its chirality and metabolic stability. It serves as a key chiral building block in the synthesis of novel drugs, particularly peptidomimetics and bioactive molecules, where its rigid pyrrolidine ring helps to fine‑tune conformation, enhance proteolytic resistance, and improve target specificity.
CAS Number
344-25-2
Stability and Storage Conditions
Hygroscopic
Solubility
Methanol (Slightly), Water (Sparingly)
Storage
Inert atmosphere,Room Temperature
Boiling Point
215.41°C (rough estimate)
Melting Point
223 °C (dec.) (lit.)
Density
1.36
Applications
D‑Proline is primarily employed as a chiral synthon and structural motif in advanced drug discovery and development. Its key applications include: serving as a critical building block for designing peptidomimetics and constrained peptides with enhanced metabolic stability and receptor selectivity; acting as a precursor or intermediate in the synthesis of novel small‑molecule active pharmaceutical ingredients (APIs); and being utilized in specialized diagnostic reagents and as a tool molecule in biochemical and pharmacological research to probe stereoselective biological processes. While not used directly as a therapeutic agent, its unique stereochemical and conformational properties make it a valuable component in the creation of next‑generation pharmaceuticals.
Color
White to yellow
MDL number
MFCD00064317
InChI Key
ONIBWKKTOPOVIA-SCSAIBSYSA-N
WGK Germany
3
LogP
-0.060 (est)
Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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