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Decitabine
Product Details
Molecular Formula
C8H12N4O4
Molecular Weight
228.21
Appearance
White to Off-white
Grade
Pharmaceutical grade
Standard
USP
Description
Decitabine is a cytidine nucleoside analog that incorporates into DNA. Its primary action is the potent and irreversible inhibition of DNA methyltransferase, leading to genome-wide DNA hypomethylation. This epigenetic modulation reactivates silenced tumor suppressor genes and genes involved in differentiation, promoting apoptosis and restoring normal function to abnormal hematopoietic blasts.
CAS Number
2353-33-5
Stability and Storage Conditions
Stable. May be light or air sensitive. Incompatible with strong oxidizing agents.
Solubility
Acetic acid/water (1:1): 50 mg/mL
Storage
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Boiling Point
370.01°C (rough estimate)
Melting Point
~200 °C (dec.)
Applications
Decitabine is a hypomethylating antineoplastic agent primarily used in the treatment of myeloid hematologic malignancies.
EC Number
219-089-4
Color
White to Off-white
MDL number
MFCD00043011
InChI Key
XAUDJQYHKZQPEU-KVQBGUIXSA-N
WGK Germany
3
RTECS
XZ3012000
Toxicity
LD50 in mice (mg/kg): 190 i.p. (Momparler, 1985)
F
10-34
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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