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Epinastine hydrochloride
Product Details
Molecular Formula
C16H16ClN3
Molecular Weight
285.77
Appearance
Powder
Grade
Pharmaceutical grade
Standard
USP
Description
Epinastine hydrochloride is the hydrochloride salt form of epinastine, serving as the active pharmaceutical ingredient (API) classified as a direct H1-receptor antagonist and mast cell stabilizer with additional anti-inflammatory properties. It works through a dual mechanism by competitively blocking histamine binding at peripheral H1 receptors and inhibiting the release of inflammatory mediators such as histamine, leukotrienes, and tryptase from mast cells.
CAS Number
80012-44-8
Stability and Storage Conditions
Photosensitive
Solubility
Freely soluble in water and methanol, soluble in ethanol, and practically insoluble in nonpolar organic solvents.
Storage
Store in a tightly closed, light-resistant container under cool, dry conditions, preferably at room temperature or below.
Melting Point
245–250°C
Applications
The Epinastine hydrochloride API is primarily used in the manufacture of ophthalmic solutions for the treatment of allergic conjunctivitis, where it relieves ocular itching, redness, and swelling. It is also formulated in oral tablets (in certain markets) for systemic management of allergic conditions such as allergic rhinitis, urticaria, and eczema, providing both rapid symptom relief and preventive anti-allergic effects.
EC Number
1312995-182-4
Color
White
MDL number
MFCD00933434
SMILES
N12C(N)=NCC1C1=CC=CC=C1CC1=CC=CC=C12.[H]Cl
InChI
InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
InChI Key
VKXSGUIOOQPGAF-UHFFFAOYSA-N
Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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