Hectorite

cid3

142

Category

Adsorbents; Emulsifiers

Molecular Formula

Na0.3(Mg,Li)3Si4O10(F,OH)2

Molecular Weight

≈383

Grade

Pharmceutical Excipients

Description

Hectorite is a naturally occurring 2 : 1 phyllosilicate clay of the smectite (montmorillonite) group and is a principal component of bentonite clay. Hectorite occurs as an odorless, white to cream colored, waxy, dull powder composed of aggregates of colloidal sized lath-shaped crystals.

UNII

08X4KI73EZ

Chemical Name

Hectorite

CAS Number

12173-47-6

Synonyms

Hector clay; Hectabrite AW; Hectabrite DP; Ghassoulite; Laponite; SHCa-1; Strese & Hofmann’s Hectorite.

Stability and Storage Conditions

Hectorite is a stable material and should be stored in a cool, dry place.

Applications

Hectorite is used widely in pharmaceutical preparations as an absorbent, emulsifier, stabilizer, suspending agent, thickener, and viscosity-controlling agent. Hectorite is a component of other naturally occurring clays and hence may be suitable for use in similar pharmaceutical formulation applications as an adsorbent, oil-in-water emulsifying agent,suspending agent, or viscosity-increasing agent. It is also available as a synthetic material. Hectorite is used to modify the thixotropic behavior of pharmaceutical dispersions and for stabilizing oil-in water emulsion bases.When combined with an appropriatecation, hectorite exhibits properties suitable for use as a contrast agent.

Safety

Hectorite is a natural clay mineral that is not considered acutely toxic; therefore no toxicity values have been established. However,hectorite may contain small amounts of crystalline silica in the form of quartz. Dust can be irritating to the respiratory tract and eyes,and contact with this material may cause drying of the skin. Chronic exposure to crystalline silica may have adverse effects on the respiratory system.

Incompatibilities

Contact between hectorite and hydrofluoric acid may generate heat.