Products

Hydroxypropyl Betadex

Product Name
Hydroxypropyl Betadex
Cat.No.
PE-0341
Particle Size
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Product Details

Category
Solubilizing Agents; Stabilizing Agents
Molecular Formula
C42H70O35(C3H6O)x
Grade
Pharmceutical Excipients
Description
Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
UNII
1I96OHX6EK
Chemical Name
β-Cyclodextrin, 2-hydroxypropyl ether
CAS Number
128446-35-5
Synonyms
Cavasol W7; 2-hydroxypropyl-b-cyclodextrin; 2-hydroxypropyl cyclomaltoheptaose; hidroksipropilbetadeksas; hydoxipropylbeta- dex; hydroksipropylbetadeksi; hydroxypropylbetadeksum; hydro- xypropylbetadexum; Kleptose HPB
Administration route
Injectable
Dosage Form
Injectable preparation
Stability and Storage Conditions
Store in well-closed containers.
Source and Preparation
Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of β-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
Applications
Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids, oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials.The reported advantage of hydroxypropyl betadex over unsubstituted β -cyclodextrin is its greater water solubility.
Safety
The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.
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