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Irinotecan hydrochloride
Product Details
Molecular Formula
C33H39ClN4O6
Molecular Weight
623.15
Appearance
Yellow powder
Grade
Pharmaceutical grade
Standard
USP
Description
Irinotecan hydrochloride is a prodrug metabolized to its active form, SN-38. This active metabolite inhibits topoisomerase I, an enzyme essential for DNA replication and transcription. Inhibition leads to stabilized DNA-topoisomerase I complexes, resulting in irreversible DNA double-strand breaks and apoptosis during the S-phase of the cell cycle.
CAS Number
100286-90-6
Stability and Storage Conditions
Stable
Solubility
Soluble in DMSO or DMF at approximately 20mg/ml. Sparingly soluble in aqueous buffers. /n
Storage
2-8°C
Boiling Point
257 °C
Melting Point
250-256°C (dec.)
Applications
Irinotecan hydrochloride is a topoisomerase I inhibitor chemotherapeutic agent primarily used in the treatment of metastatic colorectal cancer.
Color
White to yellow
MDL number
MFCD01862255
SMILES
C(C1C2=CC(OC(N3CCC(N4CCCCC4)CC3)=O)=CC=C2N=C2C3=CC4[C@@](C(=O)OCC=4C(=O)N3CC=12)(O)CC)C.Cl |&1:28,r|
Water Solubility
Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
WGK Germany
3
RTECS
DW1060750
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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