Methyl Cyclodextrin ; beta-Cyclodextrin methylether

Category

Solubilizing Agents

Molecular Formula

C54H94O35

Molecular Weight

1303.3

Grade

Pharmceutical Excipients

UNII

NA

Chemical Name

/

CAS Number

128446-36-6

Synonyms

MBC; BETA-CYD; BETA-W7 M18; METHYL B-CYCLODEXTRIN; METHYL-SS-CYCLODEXTRIN; Dimethyl-β-Cyclodextrin; METHYL-BETA-CYCLODEXTRIN; B-Cyclodextrin methyl ether; beta-cyclodextrin, methylethers

Source and Preparation

In this paper, methyl-β-cyclodextrin was prepared by using dimethyl sulfate as alkylation reagent. Add 2g sodium hydroxide and 30mL deionized water to a triangular bottle, then add 10g β-cyclodextrin, stir to dissolve. At room temperature, 5mL dimethyl sulfate was slowly added and stirred at the same time. The reaction was heated in a water bath at about 60 ℃ for 8h. After the reaction, it was cooled and adjusted to neutral with dilute hydrochloric acid. The collection liquid was distilled under vacuum pressure, concentrated to syrupy form, and slowly dropped into 40mL acetone. The product was dispersed into a powdery solid in the acetone. The acetone was filtered out and the product was vacuum dried.

Applications

Widely used in pharmaceutical, food, cosmetics, textiles and other industries. What is remarkable compared to other cyclodextrins is its ability to incorporate oil-soluble molecules.

Incompatibilities

The presence of cyclodextrins in aqueous solutions may reduce the activity of some antibacterial preservatives.