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Methyl cyclodextrin
Product Name
Methyl cyclodextrin
Cat.No.
CDC10-0747
Particle Size
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Price
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Product Details
Appearance
White powder
Grade
Cosmetic grade
Standard
Enterprise (in-house) standard; USP/EP grade available.
Description
Methyl-β-cyclodextrin (MβCD) is a methylated derivative of β-cyclodextrin, a cyclic oligosaccharide composed of seven glucopyranose units. Methylation significantly enhances its water solubility compared to native β-cyclodextrin. It has a hydrophobic inner cavity and a hydrophilic exterior, enabling it to form inclusion complexes with poorly soluble molecules. It is particularly effective at incorporating oil-soluble molecules. In cosmetics, it reduces skin irritation, enhances stability, prevents volatilisation and oxidation of nutrients, promotes transdermal absorption of active ingredients, and masks unpleasant odours.
CAS Number
128446-36-6
Stability and Storage Conditions
Stable under normal conditions. Store in a tightly closed container at room temperature (recommended +20°C / room temp). Protect from moisture and light.
Purity
≥98.0%
Solubility
Freely soluble in water; soluble in cold water; soluble in organic solvents such as ethanol, methanol, and chloroform. Achieves up to 50 mg/mL or higher concentrations in water
Storage
Store in a sealed container, protected from light and moisture, at room temperature (approx. +20°C)
Melting Point
180–182°C
Applications
Cosmetics: Reduces skin irritation; enhances stability of active ingredients; prevents volatilisation and oxidation; promotes transdermal penetration; masks unpleasant odours; maintains skin moisture; reduces microbial contamination
Safety
Low toxicity profile. Methyl-β-cyclodextrin has been shown to induce caspase-dependent apoptosis in PEL cells with no significant adverse effects. In cosmetics, it reduces skin irritation compared to native β-cyclodextrin. May have haemolytic activity due to its surface activity.
SMILES
COCC1C2C(C(C(O1)OC3C(OC(C(C3O)OC)OC4C(OC(C(C4O)OC)OC5C(OC(C(C5O)OC)OC6C(OC(C(C6O)OC)OC7C(OC(C(C7O)OC)OC8C(OC(O2)C(C8O)OC)COC)COC)COC)COC)COC)OC)O; also provided as O1C2OC...
InChI
1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59
Stability
Stable under recommended storage conditions. Enhanced stability compared to native cyclodextrins.
Water Solubility
Freely soluble in water; soluble in cold water; achieves up to 50 mg/mL or higher.
InChI Key
QGKBSGBYSPTPKJ-UHFFFAOYSA-N; also YZOUYRAONFXZSI-SBHWVFSVSA-N
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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