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Octyldodecanol
Product Details
Category
Emollient; Emulsifying Agents; Lubricant; Solvent; Thickening Agents
Molecular Formula
C20H42O
Molecular Weight
298.62
Grade
Pharmceutical Excipients
Description
Octyldodecanol occurs as a clear, colorless, or yellowish, oily liquid.
UNII
461N1O614Y
Chemical Name
Octyldodecanol
CAS Number
5333-42-6
Synonyms
Eutanol G PH; isoarachidyl alcohol; Jarcol 1-20; Jeecol ODD; octildodecanol; octyldodecanolum; 2-octyldodecyl alcohol; 2-octyl1-dodecanol; 2-octyldodecanol; Standamul G
Administration route
Topical, transdermal, and vaginal
Dosage Form
Topical, transdermal, and vaginal preparations
Stability and Storage Conditions
The bulk material should be stored in a well-closed container in a cool, dry place, protected from light. In the original unopened container, octyldodecanol can be stored for 2 years protected from moisture at below 30℃.
Source and Preparation
Octyldodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants.
Applications
Octyldodecanol is widely used in cosmetics and pharmaceutical applications as an emulsifying and opacifying agent. It is primarily used in topical applications because of its lubricating and emollient properties. Octyldodecanol has been used in the preparation of oil/water microemulsions investigated as the vehicle for the dermal administration of drugs having no or low skin penetration.Octyldodecanol has also been evaluated as a solvent for naproxen when applied topically.Studies of estimated permeability coefficient suggest that octyldodecanol could be a potential dermal permeation enhancer.
Safety
Octyldodecanol is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient. In acute oral toxicity studies in rats fed 5 g/kg of undiluted octyldodecanol, no deaths were observed.In an acute dermal toxicity study, intact and abraded skin sites of guinea pigs were treated with 3 g/kg of undiluted octyldodecanol under occlusive patches; no deaths occurred and no gross skin lesions were observed. Octyldodecanol caused either no ocular irritation or minimal, transient irritation in the eyes of rabbits. However, some sources describe undiluted octyldodecanol as an eye and severe skin irritant.
Incompatibilities
Octyldodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.
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