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Oleyl Alcohol
Product Details
Category
Antifoaming Agents; emollient; EmulsifyingAgents; Skin Penetrant; Sustained-release Agents
Molecular Formula
C18H36O
Molecular Weight
268.48
Grade
Pharmceutical Excipients
Description
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.
UNII
172F2WN8DV
Chemical Name
(Z)-9-Octadecen-1-ol
CAS Number
143-28-2
Synonyms
Alcohol oleicus; HD-Eutanol V PH; Novol; Ocenol; cis-9- octadecen-1-ol; oleic alcohol; oleo alcohol; oleol
Administration route
Topical
Dosage Form
Topical emulsions and ointments
Stability and Storage Conditions
The bulk material should be stored in a well-closed container in a cool, dry, place.
Source and Preparation
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault-Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.
Applications
Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers, and in aerosol formulations of insulin and albuterol. Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation.
Safety
Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported. The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats.
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