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Pentetic Acid
Product Details
Category
Antimicrobial Preservative; Chelating Agents; Sequestering Agents; Stabilizing Agents
Molecular Formula
C14H23N3O10
Molecular Weight
393.35
Grade
Pharmceutical Excipients
Description
Pentetic acid occurs as a white crystalline solid and is almost odorless.
UNII
7A314HQM0I
Chemical Name
2-[Bis[2-(bis(carboxymethyl)amino)ethyl]amino]acetic acid
CAS Number
67-43-6
Synonyms
Acidicum penteticum; N, N-bis[2-[bis(carboxymethyl)amino]ethyl]- glycine; [[(carboxymethyl)imino]bis(ethylenenitrilo)]tetraacetic acid; diethylenetriamine pentaacetic acid; diethylenetriamine- N, N, N 0 , N 0 , N 00 -pentaacetic acid; (diethylenetrinitrilo)pentaacetic acid; DTPA; glycine, N, N-bis[2-[bis(carboxymethyl)amino]ethyl]; pentacarboxymethyl diethylenetriamine; Versenex; ZK-43649
Administration route
Intrathecal and intravenous
Dosage Form
Intrathecal and intravenous injections
Stability and Storage Conditions
Pentetic acid should be stored in well-closed containers in a cool, dry place.
Source and Preparation
Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
Applications
Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging. It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy. Pentetic acid-isotope complexes have also been considered as model active substances in scintigraphic imaging studies. Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
Safety
Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route. LD50 (mouse, IP): 0.54 g/kg LD50 (mouse, oral): 4.84 g/kg
Incompatibilities
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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