Products

Polycarbophil

Product Name
Polycarbophil
Cat.No.
PE0366
Particle Size
Inquiry
Price

Product Details

Category
Adsorbents; Controlled-release agents; Suspending agents; Binders; Thickeners
Grade
Pharmceutical Excipients
Description
Polycarbophil occurs as fluffy, white to off-white, mildly acidic polymer powder with slightly acetic odor.
UNII
W25LM17A4W
Chemical Name
Polycarbophil
CAS Number
9003-97-8
Synonyms
Noveon AA-1.
Administration route
Buccal; Ophhalmic; Topical
Dosage Form
Film; Tablet; Gel; Solution; Suspension/Drops
Stability and Storage Conditions
Polycarbophil polymers are stable, hygroscopic materials. They do not undergo hydrolysis or oxidation under normal conditions. ners necessitates a pH greater than 7.7 to prolong polycarbophil stability.
Applications
Conventionally, polycarbophil is used as a thickening agent at very low concentrations (less than 1%) to produce a wide range of viscosities and flow properties in topical lotions, creams, and gels, in oral suspensions, and in transdermal gel reservoirs. It is also used as an emulsifying agent in topical oil-in-water systems. Polycarbophil is an excellent bioadhesive in buccal, ophthalmic, intestinal, nasal, vaginal, and rectal applications. Buccal tablets prepared using polycarbophil have shown high bioadhesive force and prolonged residence time, and proved to be nonirritative in in vivo trials with human buccal mucosa.
Safety
Polycarbophil polymers have a long history of safe and effective use in topical gels, creams, lotions, and ointments. They have been shown to have extremely low irritancy properties and are nonsensitizing with repeated usage. The use of these polymers is supported by extensive toxicological studies.
Incompatibilities
Heat may be generated if polycarbophil comes into contact with strong basic materials such as ammonia, sodium hydroxide, potassium hydroxide, or strongly basic amines. Polycarbophil polymers are not compatible with cationic polymers, strong acids, and high levels of electrolytes, as electrolytes tend to reduce the viscosity of polycarbophil-based gels.
Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
GET IN TOUCH
Enter your email here to subscribe.

Easy access to products and services you need from our library via powerful searching tools.

Copyright © CD Formulation. All Rights Reserved.  Privacy Policy | Cookie Policy