Products

Polyethylene Glycol 6000

Product Name
Polyethylene Glycol 6000
Cat.No.
PE-0441
Particle Size
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Product Details

Category
Dispersants
Molecular Formula
HOCH2(CH2OCH2)nCH2OH, n=165-210
Grade
Pharmceutical Excipients
Description
Polyethylene glycol as being an addition polymer of ethylene oxide and water. Polyethylene glycol grades 200-600 are liquids; grades 1000 and above are solids at ambient temperatures.
Liquid grades (PEG 200-600) occur as clear, colorless or slightly yellow-colored, viscous liquids. They have a slight but characteristic odor and a bitter, slightly burning taste. PEG 600 can occur as a solid at ambient temperatures. Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes. They have a faint, sweet odor. Grades of PEG 6004 and above are available as free flowing milled powders
UNII
30IQX730WE
Chemical Name
Polyethylene Glycol 6000
CAS Number
25322-68-3
Synonyms
Macrogol 6000
Administration route
Oral; Sublingual; Rectal; Vaginal
Dosage Form
Tablets (including sustained and controlled release, etc.), capsules, suppositories, creams, inserts
Stability and Storage Conditions
Sealed and stored in a dry place.
Commonly used amount and the maximum amount
The maximum dosage of each route of administration: oral: 750mg; rectum, cavity, urethra: 4.05g; general topical preparations: 75mg/g; transdermal: 308.8mg; sublingual administration: 80mg/g; ophthalmic medication: 5mg/g ; Dental external preparations and oral medicine: 250mg.
Source and Preparation
Polyethylene glycol polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
Applications
Polyethylene glycols (PEGs) are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations. Polyethylene glycol has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Safety
LD50 (guinea pig, PO): 50g/kg;
LD50 (rat, IP): 6.8g/kg.
Incompatibilities
The chemical reactivity of polyethylene glycols is mainly confined to the two terminal hydroxyl groups, which can be either esterified or etherified. However, all grades can exhibit some oxidizing activity owing to the presence of peroxide impurities and secondary products formed by autoxidation. Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents. The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin. The preservative efficacy of the parabens may also be impaired owing to binding with polyethylene glycols. Physical effects caused by polyethylene glycol bases include softening and liquefaction in mixtures with phenol, tannic acid, and salicylic acid. Discoloration of sulfonamides and dithranol can also occur, and sorbitol may be precipitated from mixtures. Plastics, such as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved by polyethylene glycols. Migration of polyethylene glycol can occur from tablet film coatings, leading to interaction with core components.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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