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Polyoxylglycerides
Product Details
Category
Emulsifying Agents; Nonionic Surfactant; Penetration Agents; Solubilizing Agents; Sustained-release Agents
Grade
Pharmceutical Excipients
Description
Polyoxylglycerides are inert liquid or semi-solid waxy materials and are amphiphilic in character. Caprylocaproyl polyoxylglycerides are pale-yellow oily liquids. Lauroyl polyoxylglycerides and stearoyl polyoxylglycerides occur as pale-yellow waxy solids. Oleoyl polyoxylglycerides and linoleoyl polyoxylglycerides occur as amber oily liquids, which may give rise to a deposit after prolonged periods at 20℃.
UNII
NA
Chemical Name
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CAS Number
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Synonyms
Polyoxylglycerides are referred to as macrogolglycerides in Europe
Administration route
Oral; topical; vaginal
Dosage Form
Oral route: capsules, tablets, solutions; topical route: emulsions, creams, lotions; vaginal route: emulsions, creams
Stability and Storage Conditions
Polyoxylglycerides are very stable and inert. However, preventive measures against the risk of oxidation or hydrolysis may be taken to ensure stability during handling. Polyoxylglycerides should be preserved in their original containers, and exposure to air, light, heat, and moisture should be prevented.
Source and Preparation
Polyoxylglycerides are obtained by partial alcoholysis of vegetable oils using macrogols, by esterification of glycerol and macrogols with unsaturated fatty acids, or by mixing glycerol esters and condensates of ethylene oxide with the fatty acids of the vegetable oil.
Applications
Polyoxylglycerides are used as self-emulsifying and solubilizing agents in oral and topical pharmaceutical formulations. They are also used in cosmetic and food products.
Safety
Polyoxylglycerides are used in oral and topical pharmaceutical formulations, and also in cosmetics and food products. They are generally regarded as relatively nonirritant and nontoxic materials. Caprylocaproyl polyoxylglycerides: LD50 (rat, oral): >22 ml/(kg day). Lauroyl polyoxylglycerides: LD50 (rat, oral): >2004 mg/(kg day).
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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