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Sorbitan Trioleate(span 85)
Product Details
Category
Surfactant; Emulsifier; Lubricant; Humectants; Dispersant; Thickener; Defoamer
Molecular Formula
C60H108O8
Molecular Weight
957.49
Grade
Pharmceutical Excipients
Description
This product is an amber viscous liquid.
UNII
QE6F49RPJ1
Chemical Name
(Z, Z, Z)-Sorbitan tri-9-octadecenoate
CAS Number
26266-58-0
Synonyms
Ablunol S-85; Arlacel 85; Crill 45; Glycomul TO; Hodag STO; Liposorb TO; Montane 85; Nissan Nonion OP-85R; Protachem STO; Protesorb STO; S-Maz 85K; Sorbester P37; sorbitani trioleas; Span 85; Tego STO
Administration route
Inhalation; Nasal Administration; Oral; Topical
Dosage Form
Oral inhalation, topical formulation
Stability and Storage Conditions
Gradually saponified under strong acid or strong base; stable in weak acid or weak base. It should be packed in an airtight container and stored in a cool and dry place.
Source and Preparation
This product is a mixture of sorbitol mono-dehydrate, di-dehydrate and three molecules of oleic acid. Its production method is to firstly dehydrate sorbitol at 150-152°C, and esterify it with three molecules of oleic acid under the catalysis of sodium bicarbonate. Or it can be prepared by direct esterification of α-sorbitol and three molecules of oleic acid at 180-280°C.
Applications
This product is used as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer, etc.
Safety
Sorbitan ester is widely used in cosmetics, food, oral and topical pharmaceutical preparations, and is generally considered non-toxic and non-irritating. However, there have been occasional reports of allergic reactions to topical agents containing sorbitan cilexetil. Sorbitan ester emits irritating fumes when heated to decomposition temperature.
Incompatibilities
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