Wax, Microcrystalline

Category

Carrier Excipients

Molecular Weight

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Grade

Pharmceutical Excipients

Description

Microcrystalline wax occurs as odorless and tasteless waxy lumps or flakes containing small irregularly shaped crystals. It may vary in color from white to yellow, amber, brown, or black depending on the grade of material; pharmaceutical grades are usually white or yellow. The USP describes microcrystalline wax as a mixture of straight-chain, branched-chain, and cyclic hydrocarbons, obtained by solvent fractionation of the still-bottom fraction of petroleum by suitable means of dewaxing or de-oiling.

UNII

XOF597Q3KY

Chemical Name

Microcrystalline wax

CAS Number

63231-60-7

Synonyms

Amorphous wax; E907; petroleum ceresin; petroleum wax (microcrystalline)

Administration route

Oral; topical and vaginal

Dosage Form

Oral capsules; topical and vaginal preparations

Stability and Storage Conditions

Microcrystalline wax is stable in the presence of acids, alkalis, light, and air. The bulk material should be stored in a well-closed container in a cool, dry place.

Source and Preparation

Microcrystalline wax is obtained by solvent fractionation of the still-bottom fraction of petroleum by suitable dewaxing or deoiling.

Applications

Microcrystalline wax is used mainly as a stiffening agent in topical creams and ointments. The wax is used to modify the crystal structure of other waxes (particularly paraffin wax) present in a mixture so that changes in crystal structure, usually exhibited over a period of time, do not occur. Microcrystalline wax also minimizes the sweating or bleeding of oils from blends of oils and waxes. Microcrystalline wax generally has a higher melting point than paraffin wax, and higher viscosity when molten, thereby increasing the consistency of creams and ointments when incorporated into such formulations. Microcrystalline wax is also used in oral controlled-release matrix pellet formulations for various active compounds and as a tablet- and capsule-coating agent. In controlled-release systems, microcrystalline wax coatings can also be used to affect the release of drug from ion-exchange resin beads. Microcrystalline wax is also used in confectionery, cosmetics, and food products.

Safety

Microcrystalline wax is mainly used in topical pharmaceutical formulations but is also used in some oral products. It is generally regarded as a nontoxic and nonirritating material.

Incompatibilities

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